Genetic quality assurance and genetic monitoring of laboratory murines


In the past years the number of mouse and rat models has increased dramatically. This is partly due to a variety of techniques developed to manipulate the genome in a targeted manner, but also to the subsequent breeding experiments to generate two-, three-, and four-fold mutants. In addition many crossing experiments have been carried out to generate a huge number of conditional mutant strains. Unfortunately, the main focus in the majority of the crossing experiments lies on the manipulated loci; whereas the genetic background of the animals is often neglected. The working group will develop recommendations for the genetic quality assurance of laboratory murines. These recommendations should be a guide to animal facilities and researchers on how animal experiments can be carried out under genetically standardized conditions so that these recommendations will also contribute to the three R’s.



  • Fernando Benavides (SECAL)


  • James Bussel (LASA)
  • Paolo Cinelli (SGV)
  • Yann Herault (AFSTAL)
  • Jan-Bas Prins (NVP)
  • Thomas Ruelike (GV-SOLAS)
  • Ferdinando Scavizzi (AISAL)